2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141176
    TCO-amine 1609736-43-7
    TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-amine
  • HY-140678
    mPEG-amine (MW 10000) 80506-64-5 ≥98.0%
    mPEG-amine (mPEG-NH2) (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    mPEG-amine (MW 10000)
  • HY-140715
    HO-PEG-amine (MW 3400)
    HO-PEG-amine (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG-amine (MW 3400)
  • HY-140738
    DSPE-PEG-CH2COOH, MW 5000
    DSPE-PEG-CH2COOH, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG-CH2COOH, MW 5000
  • HY-141402
    m-PEG4-Hydrazide 1449390-68-4
    m-PEG4-Hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-Hydrazide
  • HY-140932A
    Biotin-PEG4-hydrazide TFA
    Biotin-PEG4-hydrazide (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-hydrazide TFA
  • HY-176037
    Boc-C3-amide-C10-amine
    Boc-C3-amide-C10-amine is a PROTAC linker that can be used in the synthesis of PROTAC MS479 (HY-176035).
    Boc-C3-amide-C10-amine
  • HY-140785
    Azido-PEG36-Boc
    Azido-PEG36-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG36-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG36-Boc
  • HY-130826
    Bis-PEG17-NHS ester 2221948-93-0
    Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG17-NHS ester
  • HY-130912
    DBCO-NH-(CH2)4COOH 2375193-74-9
    DBCO-NH-(CH2)4COOH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NH-(CH2)4COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NH-(CH2)4COOH
  • HY-140295
    DBCO-C3-PEG4-NH-Boc
    DBCO-C3-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-C3-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-C3-PEG4-NH-Boc
  • HY-140786
    Azido-PEG4-amido-PEG4-Boc
    Azido-PEG4-amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-amido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-amido-PEG4-Boc
  • HY-140297
    Carboxyrhodamine 110-PEG4-DBCO
    Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Carboxyrhodamine 110-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Carboxyrhodamine 110-PEG4-DBCO
  • HY-130192
    Cbz-NH-PEG8-C2-acid 1334177-87-5
    Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG8-C2-acid
  • HY-138736
    Propargyl-PEG5-Br 1287660-83-6
    Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG5-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-Br
  • HY-133191
    Bis-propargyl-PEG2 126422-57-9
    Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG2
  • HY-132080
    Bis-PEG8-t-butyl ester
    Bis-PEG8-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG8-t-butyl ester
  • HY-138389
    THP-PEG13-OH
    THP-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG13-OH
  • HY-140670
    m-PEG-acrylate (MW 2000)
    m-PEG-acrylate (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-acrylate (MW 2000)
  • HY-141030
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3 2107273-38-9
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(m-PEG4)-N'-(azide-PEG4)-Cy3
PROTAC Linkers Isoform Comparison

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